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Antigenic Specificity | JUN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total JUN protein. c-Jun is a member of the Jun Family containing c-Jun, JunB and JunD, and is a component of the transcription factor AP-1 (activator protein-1). AP-1 is composed of dimers of Fos, Jun and ATF family members and binds to and activates transcription at TRE/AP-1 elements (reviewed in 1). Extracellular signals including growth factors, chemokines and stress activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that c-Jun is essential for embryogenesis (3), and subsequent studies have demonstrated roles for c-Jun in various tissues and developme |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human JUN. |
Other Names | [JUN; AP-1; AP1; c-Jun] |
Gene, Accession # | [JUN], Gene ID: 3725, NCBI: NP_002219.1, UniProt: P05412 |
Catalog # | MBS9409299 |
Price | $255 |
Order / More Info | JUN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |