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Antigenic Specificity | NOS2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109). |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 500-730 of human NOS2 (NP 000616.3). |
Other Names | [NOS; INOS; NOS2A; HEP-NOS] |
Gene, Accession # | [NOS2], Gene ID: 4843, NCBI: NP_000616.3, UniProt: P35228 |
Catalog # | MBS8549309 |
Price | $280 |
Order / More Info | NOS2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |