Phospho-Dnmt1-pS714 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Phospho-Dnmt1-pS714 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Methylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting and development (1, 2). Three families of mammalian DNA methyltransferases have been identified: DNMT1, DNMT2 and DNMT3 (1, 2). DNMT1 is constitutively expressed in proliferating cells and functions as a maintenance methyltransferase, transferring proper methylation patterns to newly synthesized DNA during replication. DNMT3A and DNMT3B are strongly expressed in embryonic stem cells with reduced expression in adult somatic tissues. DNMT3A and DNMT3B function as de novo methyltransferases that methylate previously unmethylated regions of DNA. DNMT2 is expressed at low |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S714 of human Dnmt1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [AIM; DNMT; MCMT; CXXC9; HSN1E; FLJ16293; MGC104992; DNMT1] |
| Gene, Accession # | [Dnmt1-pS714], Gene ID: 1786, NCBI: NP_001124295.1, UniProt: P26358 |
| Catalog # | MBS8527417 |
| Price | $310 |
| Order / More Info | Phospho-Dnmt1-pS714 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Hermann, A. et al. (2004) Cell. Mol. Life Sci. 61, 2571-2587. 2. Turek-Plewa, J. and Jagodzi?ski, P.P. (2005) Cell. Mol. Biol. Lett. 10, 631-647. 3. Kim, G.D. et al. (2002) EMBO J. 21, 4183-4195. 4. Fuks, F. et al. (2001) EMBO J. 20, 2536-2544. 5. Geiman, T.M. et al. (2004) Biochem. Biophys. Res. Commun. 318, 544-555. 6. Rountree, M.R. et al. (2000) Nat. Genet. 25, 269-277. 7. Pradhan, S. and Kim, G.D. (2002) EMBO J. 21, 779-788. 8. Fuks, F. et al. (2003) Nucleic Acids Res. 31, 2305-2312. 9. Mizuno, S. et al. (2001) Blood 97, 1172-1179. 10. Robertson, K.D. et al. (1999) Nucleic Acids Res. 27, 2291-2298. 11. Xie, S. et al. (1999) Gene 236, 87-95. 12. Kanai, Y. et al. (2001) Int. J. Cancer 91, 205-212. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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