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Antigenic Specificity | ARHGEF7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, monkey |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Cool/Pix proteins comprise a family of guanine nucleotide exchange factors (GEFs) localized to focal adhesions. The family consists of two isoforms, cool2/alphapix and cool1/betaPix, the latter having two splice variants that vary in their carboxy termini (1). Cool1/betaPix, like other GEFs, has a DH (Dbl homology) domain, which allows binding of small GTPases and GDP/GTP exchange, and a PH (Pleckstrin homology) domain, which is important in regulating subcellular localization. Cool1/betaPix also has an SH3 domain, which binds to the PAK kinase, a downstream effector of cdc42 and Rac (3,4). Phosphorylation of cool1/betaPix by PAK2 downstream of MAPK signaling alters the localization of a complex containing PAK2 and cool-1/betaPix, regulatin |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [ARHGEF7; BETA-PIX; COOL1; DKFZp686C12170; DKFZp761K1021; KIAA0142; KIAA0412; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB], [ARHGEF7; ARHGEF7; P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314; COOL1; KIAA0142; P85SPR; PAK3BP; PIXB] |
Gene, Accession # | [ARHGEF7], Gene ID: 8874, NCBI: Q14155.2, UniProt: Q14155 |
Catalog # | MBS126412 |
Price | $200, $275, $430 |
Order / More Info | ARHGEF7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |