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Antigenic Specificity | PDGFR-B |
Clone | [RBT-PDGFRB] |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | IgG |
Format | unconjugated |
Size | 5 Control Slides, 3 ml (Prediluted), 0.1 mL (Concentrate) |
Concentration | n/a |
Applications | n/a |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Beta-type Platelet-Derived Growth Factor Receptor is a protein that in humans is encoded by the PDGFRB gene. This gene encodes a cell surface tyrosine kinase receptor for members of the Platelet-Derived Growth Factor family (PDGF), which is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. Translocation of the PDGFR gene with the Tel gene is linked to Chronic Myelomonocytic Leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myel |
Immunogen | Immunogen: Highly pure (>98%) recombinant hPDGF-B (human Platelet Derived Growth Factor). Localization: Cytoplasmic, Membranous. Reactivity: Paraffin, Frozen. Control: Brain, Testis, Breast, Colon, Fallopian Tube |
Other Names | n/a |
Gene, Accession # | [PDGFR-B], NCBI: AFV92359.1 |
Catalog # | MBS373051 |
Price | $130, $290, $315 |
Order / More Info | PDGFR-B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |