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Antigenic Specificity | Lipoteichoic Acid |
Clone | 55 |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG3 |
Format | unconjugated |
Size | 0.2 mg |
Concentration | >200 ug/mL |
Applications | Frozen Section (F), Flow Cytometry (FC), Immuno Assay (IA2,3,8), Immuno Fluorescence (IF4,9), Western Blot (WB5,6,7) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Product Description: The monoclonal antibody 55 recognizes lipoteichoic acid (LTA). LTA, a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. LTA is anchored via its glycolipids to the membrane and carries a polysaccharide chain extending into the peptidoglycan layer of the cell wall. LTA is released spontaneously into the culture medium during growth of gram-positive bacteria. LTA functions as an immune activator with characteristics very similar to lipopolysaccharide (LPS) from Gram-negative bacteria. LTA binds to CD14 and triggers activation predominantly via Toll-like receptor 2.- Although LTA is internalized and traffics to the Golgi, the cellular activation in response to LTA occurs at the ce |
Immunogen | Immunogen: Microbial mixture of Streptococcus sobrims HG961, HG962, HG970, and HG977. Aliases: LTA |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS584232 |
Price | $610 |
Order / More Info | Lipoteichoic Acid Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Hogg,S et al; Occurrence of lipotechoic acid in oral streptococci. Int. journal of systematic bacteriology 1997, 47:62 2. Langevelde, P et al; Antibiotic-induced release of lipoteichoic acid and peptidoglycan from Staphylococcus aureus: Quantitative measurements and biological reactivities. Antimicrob Agents Chemother 1998, 42: 3073 3. Langevelde, P et al; Antibiotic-induced cell wall fragments of Staphylococcus aureus increase endothelial chemokine secretion and adhesiveness for granulocytes. Antimicrob Agents Chemother 1999, 43: 2984 4. Triantafilou, M et al; Lipoteichoic acid and toll-like receptor 2 internalization and targeting to the golgi are lipid raft-dependent. J Biol Chem 2004, 279: 40882 5. Henneke, P et al; Role of lipoteichoic acid in the phagocyte response to group B Streptococcus. J Immunol 2005, 174: 6449 6. Grundling, A et al. Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus. PNAS 2007, 104:8478 7. Jimenez-Dalmaroni, M et al. Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. Plos One 2009, 4:7411 8. Yajima, A et al. Contribution of phosphoglucosamine mutase to the resistance of Streptococcus gordonii DL1 to polymorphonuclear leukocyte killing. FEMS Microbiol lett 2009, 297: 196 9. Hashimoto, Y et al. Identification of LTA as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes. I.Immunol 2009, 183:7451 10. Hirose, Y et al. Lipoteichoic acids on lactobacillus platarum cell surfaces correlate with induction of interleukin-12p40 production. Microbiol immunol 2010, 54:143 |