SQSTM1 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | SQSTM1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | APC-Cy7 conjugate |
| Size | 0.1 mg |
| Concentration | 1 mg/ml |
| Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Detects ~60 kDa. Band at 40 kDa is isoform 2. SQSTM1 or Sequestome 1 (p62) is a ubiquitin binding protein that interacts with ubiqutin, providing a scaffold for several signaling proteins and triggering degradation of proteins throught the proteasome or lysossome. This gene regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Mutations in this gene result in sporadic and familial Paget disease of bone. SQSTM1 also binds autophagosomal membrane protein LC3/ATG8. |
| Immunogen | Immunogen: Synthetic peptide from the N-terminal to mid of Human SQSTM1 (aa. 195-205) |
| Other Names | [Rabbit Human SQSTM1; EBI3-associated protein of 60 kDa; ORCA; Osi; SQSTM 1; ZIP 3; A170; SQSTM1; Ubiquitin binding protein p62; Protein kinase C-zeta-interacting protein; FTDALS3; Ubiquitin-binding protein p62; PKC-zeta-interacting protein; EBIAP; Sqstm1; Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa; EBI3 associated protein p60; EBI3 associated protein of 60 kDa; SQSTM_HUMAN; OSF-6; Paget disease of bone 3; p62B; p60; PDB 3; EBI 3 associated protein p60; MGC127197; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; EBI 3 associated protein of 60 kDa; ZIP3; STAP; p62; Sequestosome 1; OSIL; STONE14; Phosphotyrosine independent ligand for the Lck SH2 domain p62; PDB3; Oxidative stress induced like; Sequestosome-1; ZIP] |
| Gene, Accession # | [SQSTM1], Gene ID: 8878, NCBI: Q13501.1, UniProt: Q13501 |
| Catalog # | MBS8004727 |
| Price | $515 |
| Order / More Info | SQSTM1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kirkin V., et al. (2009) Mol Cell. 34: 259-269. 2. Seibenhener M.L., et al. (2007) FEBS Lett. 581: 175-179. 3. Komatsu M., et al. (2010) Nat Cell Biol. 12: 213-223. 4. Bjorkoy G., et al. (2006) Autophagy. 2: 138-139. 5. Pankiv S., et al. (2007) J Biol Chem. 282: 24131-24145. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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