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Antigenic Specificity | JMJD4 (N-term), 1-30 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This JMJD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human JMJD4. Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as |
Immunogen | n/a |
Other Names | [JmjC domain-containing protein 4; Jumonji domain-containing protein 4; JMJD4] |
Gene, Accession # | [JMJD4], Gene ID: 65094, NCBI: NP_001154937.1, UniProt: Q9H9V9 |
Catalog # | MBS9209350 |
Price | $165, $370 |
Order / More Info | JMJD4 (N-term), 1-30 Antibody from MYBIOSOURCE INC. |
Product Specific References | Ota, T., et al., Nat. Genet. 36(1):40-45 (2004). |