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Antigenic Specificity | Mouse CASP3 (N-term S12) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | unconjugated |
Size | 0.08 mL, 0.4 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This mouse CASP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of mouse CASP3. Description: CASP3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory proces |
Immunogen | n/a |
Other Names | [Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; LICE; Protein Yama; SREBP cleavage activity 1; SCA-1; Caspase-3 subunit p17; Caspase-3 subunit p12; Casp3; Cpp32] |
Gene, Accession # | [Casp3], Gene ID: 12367, NCBI: NP_033940.1, UniProt: P70677 |
Catalog # | MBS9217101 |
Price | $165, $370 |
Order / More Info | Mouse CASP3 (N-term S12) Antibody from MYBIOSOURCE INC. |
Product Specific References | Srikanth, C.V., et al. Science 330 (6002):390-393 (2010). Li, F., et al. Cell Stem Cell 7 (4):508-520 (2010). Wang, L., et al. J. Neurosci. 30 (39):13201-13210 (2010). Gascon, E., et al. J. Neurosci. 30 (37):12414-12423 (2010). Bohsali, A., et al. BMC Microbiol. 10, 237 (2010). |