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Antigenic Specificity | Noxa |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.2 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Noxa is a BH3-only member of the Bcl-2 family. Expression of Noxa gene involves direct activation of its promotor by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Coimmunoprecipitation data smuggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as Bcl-xL and Mcl-1. Blocking the endogenous Noxa induction results in the suppression of apoptosis. These smuggest Noxa may represent a candidate mediator of p53-induced apoptosis. |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 100 of human Noxa |
Other Names | [PMAIP1; NOXA; APR], [PMAIP1; PMAIP1; APR; NOXA; NOXA; PMA-induced protein 1] |
Gene, Accession # | [Noxa], Gene ID: 5366, NCBI: AAH32663 |
Catalog # | MBS840589 |
Price | $150, $290 |
Order / More Info | Noxa Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |