MT1 / CD43 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | MT1 / CD43 |
| Clone | [MT1] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) (frozen), Immunohistochemistry (IHC) (paraffin), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Clone MT1 produces Mouse IgG1 immunoglobulins reactive with a 95-115 kD highly sialated glycoprotein. This antibody is used to identify B cell lines and myeloma cells. It may be used in the diagnosis of chronic lymphocytic leukemias (CLL), as an alternative to CD5. The antigen detected by MT1 is the only marker expressed on neoplasms of the very early precursor cells. In immunohistochemistry it reacts with T cells, macrophages, myeloid cells and B cells (weak). It is used for the typing of lymphomas in paraffin sections. CD43 may function as an adhesion molecule via interaction with CD54 although this has not been definitely established. It may also inhibit leucocyte interactions with other cells. The antigen is involved in the |
| Immunogen | Source Note: MT1 is a monoclonal antibody derived by fusion of X63 Mouse myeloma cells with spleen cells from of Balb/c mice, intraperitoneally immunized with Human monocytes isolated by centrifugal elutriation. Immunizations were carried out at least twice at 2-week intervals with: A) cell suspensions of a lymph node involved by Hodgkin's disease; B) cell suspensions of a lymph node involved by Bchronic lymphatic leukemia; C) cells of Hodgkin's cell line DEV, respectively. No adjuvants were use |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS570291 |
| Price | $415 |
| Order / More Info | MT1 / CD43 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Barclay, A., et al. (1997). The Leucocyte antigen factsbook. Academic Press. London. Schmid, K., Hediger M.A., Brossmer, R., Collins, J.H., Haupt, H. Marti, T., Offner, G.D., Schaller, J., Takaqaki, K., Walsh, M.T., et al. (1992). Amino acid sequence of Human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). Proc Natl Acad Sci U S A 89, 663-7. Poppema, S., Hollema, H., Visser, L. and Vos, H. (1987). Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections. Am J Pathol. 127, 418-29. Poppema, S. and Visser, L. (1987). Biotest bulletin 31, 418-29. Knapp, W., et al. eds. (1989). Leucocyte typing workshop IV. Oxford university press. Manjunath, N., Correa, M., Ardman, M. and Ardman, B. (1995). Negative regulation of T-cell adhesion and activation by CD43. Nature 377, 535-8. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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