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Antigenic Specificity | SRPX1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 13 amino acid peptide from near the amino terminus of human SRPX1. |
Other Names | [Sushi-repeat-containing protein X-linked, SRPX, DRS, ETX1] |
Gene, Accession # | [SRPX1], Gene ID: 8406, NCBI: NP_006298 |
Catalog # | MBS9411167 |
Price | $320 |
Order / More Info | SRPX1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |