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Antigenic Specificity | AXL (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This AXL antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 838-872 amino acids from the C-terminal region of human AXL. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 a |
Immunogen | n/a |
Other Names | [Tyrosine-protein kinase receptor UFO; AXL oncogene; AXL; UFO] |
Gene, Accession # | [AXL], Gene ID: 558, NCBI: NP_001690.2, UniProt: P30530 |
Catalog # | MBS9203725 |
Price | $165, $370 |
Order / More Info | AXL (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Partanen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:8913-8917(1990). O'Bryan J.P.,et al.Mol. Cell. Biol. 11:5016-5031(1991). Janssen J.W.G.,et al.Oncogene 6:2113-2120(1991). Grimwood J.,et al.Nature 428:529-535(2004). Lee S.-T.,et al.Oncogene 8:3403-3410(1993). |