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Antigenic Specificity | Caspase-9 (IN2) (ICE LAP6, Mch6, Apaf-3) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3 (1-3). Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation (3). Caspase-9 is also activated by granzyme B and CPP32 (1,2). Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators i |
Immunogen | Immunogen: Synthetic peptide corresponding to amino acids 299 to 318 of human caspase-9 |
Other Names | [Cysteine-requiring Aspartate Protease-9; iCE-like apoptotic protease 6;Apoptotic protease Mch-6; Apoptotic protease-activating factor 3], [CASP9; CASP9; MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; MCH6; CASP-9; APAF-3; ICE-LAP6] |
Gene, Accession # | Gene ID: 842, NCBI: NP_001220.2, UniProt: P55211 |
Catalog # | MBS395765 |
Price | $510 |
Order / More Info | Caspase-9 (IN2) (ICE LAP6, Mch6, Apaf-3) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |