Edit |   |
---|---|
Antigenic Specificity | ALS2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [ALSJ; PLSJ; IAHSP; ALS2CR6], [ALS2; ALS2; ALSJ; PLSJ; IAHSP; ALS2CR6; ALS2CR6; KIAA1563] |
Gene, Accession # | [ALS2], Gene ID: 57679, NCBI: Q96Q42.2, UniProt: Q96Q42 |
Catalog # | MBS129628 |
Price | $200, $275, $430 |
Order / More Info | ALS2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |