PKM2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PKM2 |
| Clone | [AT1B10] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1,k |
| Format | Protein A purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | 1mg/ml |
| Applications | ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PKM2 (pyruvate kinase M2), its association with phospho-tyrosine (pTyr) motifs, enables cells to use predominantly aerobic glycolysis instead of oxidative phosphorylation. Also PKM2 suggest that this change benefits cancer cells by enabling them to redirect glycolytic metabolites away from oxidation and energy production and, instead, toward anabolic processes and biosynthesis. PKM2-mediated generation of the aerobic glycolytic phenotype, although wasteful in terms of glucose consumption and waste generation, could provide a variety of advantages for cancerous cells. In addition nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. |
| Immunogen | Immunogen: Recombinant human PKM2 (1-531aa) purified from E Coli. |
| Other Names | [pyruvate kinase muscle isoform M2; CTHBP; THBP1; p58; M2-PK; Tumor M2-PK; PK2; PK3; PKM; pyruvate kinase; muscle isoform M2 OIP3; PKM; TCB; OPA interacting protein 3; PKM2; Cytosolic thyroid hormone binding protein; Pyruvate kinase 2/3; Pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle; Thyroid hormone binding protein cytosolic; Tumour Type M2 Pyruvate Kinase; Tumor Type M2 Pyruvate Kinase], [PKM; PKM; PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-30; OIP3; PK2; PK3; PKM2; CTHBP; OIP-3; THBP1] |
| Gene, Accession # | [PKM2], Gene ID: 5315, NCBI: NP_002645, UniProt: P14618 |
| Catalog # | MBS200298 |
| Price | $240, $315 |
| Order / More Info | PKM2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Ferguson E.C., et al. (2008) Trends Biochem Sci 33 (8): 359-362; Christofk H.R., et al. (2008) Nature 452 (7184):181-186; Shimada N., et al. (2008) Genes Cells 13 (3): 245-254 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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