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Antigenic Specificity | CAD |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a peptide corresponding to 17 amino acids near the center of murine CAD. |
Other Names | [DFF40 (I17)] |
Gene, Accession # | [CAD], Gene ID: 13368, NCBI: NP_031885.3, UniProt: O54788 |
Catalog # | MBS9411044 |
Price | $320 |
Order / More Info | CAD Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |