Human ATG4C Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHuman ATG4C
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, rat
Isotypen/a
FormatPeptide Affinity purified
Size0.1 mg
Concentration1 mg/ml
ApplicationsWestern Blot (WB)
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DescriptionATG4C belongs to the peptidase C54 family. It is a cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. It also has an activity of delipidating enzyme for the PE-conjugated forms (1).
ImmunogenImmunogen: Synthetic peptide from the N-terminal of human ATG4C. Immunogen Species: Human
Other Names[APG4 autophagy 4 homolog C; APG4 C; Atg4c; AUTL1; Autophagin 3; Cysteine protease ATG4C; ATG4C : ATTO 655; Rabbit Human ATG4C; Rabbit Human ATG4C; ATG4C], [ATG4C; ATG4C; APG4C; AUTL1; AUTL3; APG4-C; APG4C; AUTL1; AUTL3]
Gene, Accession #[ATG4C], Gene ID: 84938, NCBI: NP_116241.2, UniProt: Q96DT6
Catalog #MBS807421
Price$440
Order / More InfoHuman ATG4C Antibody from MYBIOSOURCE INC.
Product Specific References1. Li M., et al. (2011) J Biol Chem. 286: 7327-7338.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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