PUMA (I17) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PUMA (I17) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.2 mg |
| Concentration | 0.200 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Mouse and human PUMA alpha and beta forms. The Bcl-2 family proteins can function to either suppress or promote cell death and are characterized by the presence of up to four conserved amino acid motifs, termed Bcl-2 homology (BH) domains (1). The BH3 function has been further revealed by an emerging group of BH3-only proteins, that includes Bik, Bad, Bid, Bim, Noxa, and the newest member PUMA or bbc3 (1&2). The PUMA gene is a target of p53 transcriptional activation and encodes two BH3 domain-containing proteins (PUMA-alpha and PUMA-beta) (3&4). The activities of PUMA-alpha and PUMA-beta are similar; they bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate extremely rapid apoptosis (3&4). |
| Immunogen | Immunogen: Synthetic peptide mapping to an internal domain of human PUMA. |
| Other Names | [PUMA; Bcl-2-binding component 3; bcl-2-binding component 3; p53 up-regulated modulator of apoptosis; Bcl-2 binding component 3; p53 up-regulated modulator of apoptosis], [Bbc3; Bbc3; Puma; Puma] |
| Gene, Accession # | [PUMA], Gene ID: 317673, NCBI: AAO16862.1, UniProt: Q80ZG6 |
| Catalog # | MBS440040 |
| Price | $240 |
| Order / More Info | PUMA (I17) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1.) Goldberg Z, Levav Y, Krichevsky S, Fibach E, Haupt Y. 2004. Treatment of chronic myeloid leukemia cells with imatinib (STI571) impairs p53 accumulation in response to DNA damage. Cell Cycle. Sep;3(9):1188-95.1. Han J., Flemington C., Houghton A.B., Gu Z., Zambetti G.P., Lutz R.J., Zhu L., Chittenden T. 2001. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. PNAS 98(20):11318-11323.2. Schuler M., Green D.R. 2001. Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 29(Pt6):684-688.3. Nakano K., Vousden K.H. 2001. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7(3):683-694.4. Yu J., Zhang L., Hwang P.M., Kinzler K.W., Vogelstein B. 2001. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 7(3):673-682. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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