APEX Nuclease I Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | APEX Nuclease I |
| Clone | [CPTC-APEX1-2] |
| Host Species | Mouse |
| Reactive Species | human. |
| Isotype | IgG1 |
| Format | purified |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistology (Formalin-Fixed) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: APEX/APE1 is a multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Patients with genetic variants in APEX1 and XRCC1 have been shown to have a higher risk of lung cancer. Elevated APEX1 levels observed in human testicular cancer may be related to relative resistance to therapy and therefore may serve as a diagnostic marker for refractory disease. |
| Immunogen | Immunogen: Recombinant human full-length APEX1protein Positive Control: HeLa, NIH/3T3 and C6 whole cell lysates. Human ovarian carcinoma. |
| Other Names | [APEX1; AP endonuclease class I; AP lyase; APE; APE-1; APEN; APEX nuclease; Redox factor-1; APX; protein REF-1] |
| Gene, Accession # | [PTPN6], Gene ID: 328, NCBI: NP_001231178.1, UniProt: P27695 |
| Catalog # | MBS4380592 |
| Price | $190, $340, $340 |
| Order / More Info | APEX Nuclease I Antibody from MYBIOSOURCE INC. |
| Product Specific References | Robertson, K.A., et al. Cancer Res. 2001.; Xuan, W. et al. Anticancer Res. 200 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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