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Antigenic Specificity | TRIM28 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activi |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 576-835 of human TRIM28 (NP 005753.1). |
Other Names | [KAP1; TF1B; RNF96; TIF1B; PPP1R157] |
Gene, Accession # | [TRIM28], Gene ID: 10155, NCBI: Q13263.5, UniProt: Q13263 |
Catalog # | MBS8544885 |
Price | $280 |
Order / More Info | TRIM28 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |