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Antigenic Specificity | Bfl-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells. At least two isoforms of Bfl-1 are known to exist. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 14 amino acid peptide from near the amino terminus of human Bfl-1. |
Other Names | [Bcl-2-related protein A1, Hemopoietic-specific early response protein] |
Gene, Accession # | [Bfl-1], Gene ID: 597, NCBI: NP_004040 |
Catalog # | MBS9405800 |
Price | $320 |
Order / More Info | Bfl-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |