UIMC1 (C-term) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | UIMC1 (C-term) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.36 |
| Applications | Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This UIMC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 567-601 amino acids from the C-terminal region of human UIMC1. Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with |
| Immunogen | n/a |
| Other Names | [BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1; UIMC1; RAP80; RXRIP110] |
| Gene, Accession # | [UIMC1], Gene ID: 51720, NCBI: NP_001186226.1, UniProt: Q96RL1 |
| Catalog # | MBS9203423 |
| Price | $165, $370 |
| Order / More Info | UIMC1 (C-term) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Yan Z.,et al.J. Biol. Chem. 277:32379-32388(2002). Peng Y.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases. Xu X.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. Ota T.,et al.Nat. Genet. 36:40-45(2004). Bechtel S.,et al.BMC Genomics 8:399-399(2007). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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