Calreticulin Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityCalreticulin
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat, bovine, dog, chicken, guinea pig, monkey, porcine, hamster, rabbit, sheep
Isotypen/a
FormatATTO 700 conjugate
Size0.2 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Immunofluorescence (IF)
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DescriptionBackground Info: Detects ~63kDa. Scientific Background: Calreticulin is a multifunctional, highly conserved Ca2 -binding protein that is localized to the endoplasmic reticulum (ER), but has also been detected in the nucleus and nuclear envelop. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus (1-3). CRT's three domains include a 180 residue N-terminal domain, a proline-rich P-domain (residues 189-288) that binds Ca2 with high affinity and shares homology with calnexin (CNX) and calmegin, and a 110 residue C-terminal domain that binds Ca2 with low affinity but high capacity (1,3). Recent studies suggest that this soluble ER protein has a multifunctional role. It appears to be in
Immunogenn/a
Other Names[CALR; Calregulin; cC1qR; CRP55; ERp60; HSCBP; RO; SSA; grp60], [CALR; CALR; RO; CRT; SSA; cC1qR; HEL-S-99n; CRTC; ERp60]
Gene, Accession #Gene ID: 811, NCBI: NP_004334.1, UniProt: P27797
Catalog #MBS805698
Price$430
Order / More InfoCalreticulin Antibody from MYBIOSOURCE INC.
Product Specific References1. Johnson S., et al. (2001) Trends Cell Biol 11: 122-129. 2. Smith M.J., et al. (1989) EMBO J. 8: 3581-3586. 3. Ellgaard L., et al. (2001) Curr Opin Cell Biol. 13: 431- 437. 4. Krause K.H., and Michalak M. (1997) Cell. 88: 439- 443. 5. Nash P.D., et al. (1994) Mol Cell Biochem. 135: 71-78. 6. Heal R., and McGivan J. (1998) Biochem J. 329: 389- 394. 7. Lucero H.A., et al. (1998) J Biol Chem. 273: 9857- 9863. 8. Tanaka S., et al. (2000) J Biol Chem. 275: 10388- 10393. 9. Yoon G.S., et al. (2000) Cancer Res. 60: 1117-1120. 10. Antoniou A.N., et al. (2002) Immunology 106: 182- 189. 11. Wada I., et al. (1997) EMBO J. 16: 5420-5432. 12. Laguerre D.B., et al. (1998) J Vir. 72: 4940-4949.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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