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Antigenic Specificity | ATF4 |
Clone | [S360A-24] |
Host Species | Mouse |
Reactive Species | human, rat |
Isotype | IgG2a |
Format | fluorescein (FITC) conjugate |
Size | 0.1 mg |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background Info: Detects 60 kDa protein. Does not cross-react with ATF5 Scientific Background: Cyclic AMP-dependent transcription factor ATF-4 (ATF4) is a basic leucine-zipper (bZip) transcription factor, which regulates amino acid metabolism, DNA damage repair, chromatin remodeling, and apoptosis in response to cellular and ER stress. ATF4 works with various proteins, such as C/EBP homology protein (CHOP), aspargine synthetase (ASNS), and cAMP response element (CRE) among others to mediate cellular stress. ATF4 also regulates glucose homeostasis by suppressing beta-cell proliferation and insulin production. Furthermore, ATF4 targets the histone demethylase JMJD3 to alter chromatin structure and enhance gene transcription in response to ami |
Immunogen | n/a |
Other Names | [Activating Transcription Factor 4; ATF 4; ATF4 protein; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB 2; CREB-2; CREB2; Cyclic AMP dependent transcription factor ATF 4], [ATF4; ATF4; CREB2; TXREB; CREB-2; TAXREB67; CREB2; TXREB; cAMP-dependent transcription factor ATF-4; CREB-2; cAMP-responsive element-binding protein 2; TaxREB67] |
Gene, Accession # | Gene ID: 468, NCBI: NP_001666.2, UniProt: P18848 |
Catalog # | MBS800297 |
Price | $430 |
Order / More Info | ATF4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |