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Antigenic Specificity | SMYD2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SMYD2 (NP 064582.2). |
Other Names | [KMT3C; HSKM-B; ZMYND14] |
Gene, Accession # | [SMYD2], Gene ID: 56950, NCBI: Q9NRG4.2, UniProt: Q9NRG4 |
Catalog # | MBS8546138 |
Price | $280 |
Order / More Info | SMYD2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |