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Antigenic Specificity | ARC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK BCL10, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a peptide corresponding to amino acids 2 to 18 of human origin. These sequences are identical to those of human nuclear protein Nop30 (2) and differ from those of the rat homolog of ARC by one amino acid (3). |
Other Names | [ARC] |
Gene, Accession # | [ARC], Gene ID: 8996, NCBI: NP_003937 |
Catalog # | MBS9411658 |
Price | $320 |
Order / More Info | ARC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |