Caspase-12 (IN) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Caspase-12 (IN) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer?s disease including -secretase presenilin and -amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amylo |
| Immunogen | Immunogen: Synthetic peptide corresponding to amino acids 100 to 116 of the murine caspase-12 |
| Other Names | [inactive caspase-12; Inactive caspase-12; inactive caspase-12; caspase 12 pseudogene 1; caspase 12 (gene/pseudogene)], [CASP12; CASP12; CASP-12; CASP12P1; CASP-12] |
| Gene, Accession # | Gene ID: 100506742, NCBI: NP_001177945.1, UniProt: Q6UXS9 |
| Catalog # | MBS395820 |
| Price | $510 |
| Order / More Info | Caspase-12 (IN) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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