Edit |   |
---|---|
Antigenic Specificity | ELF4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. |
Immunogen | Immunogen: Recombinant human ETS-related transcription factor Elf-4 protein(1-200aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-132290 / sc-132292 / sc-101947 |
Other Names | [E74-like factor 4; Myeloid Elf-1-like factor; ELF4], [ELF4; ELF4; MEF; ELFR] |
Gene, Accession # | [ELF4], Gene ID: 2000, NCBI: NP_001120669.1, UniProt: Q99607 |
Catalog # | MBS1498077 |
Price | $120, $160 |
Order / More Info | ELF4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |