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Antigenic Specificity | FOXO3 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). |
Immunogen | Immunogen: A synthesized peptide derived from human FOXO3 |
Other Names | [Forkhead box protein O3; AF6q21 protein; FOXO3] |
Gene, Accession # | [FOXO3], Gene ID: 2309, NCBI: NP_001446.1, UniProt: O43524 |
Catalog # | MBS7114817 |
Price | $185, $265 |
Order / More Info | FOXO3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |