PTPRC Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | PTPRC |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The protein phosphatase (PTP) receptor CD45 is a type I transmembrane protein comprised of a pair of intracellular tyrosine phosphatase domains and a variable extracellular domain generated by alternative splicing (1). The catalytic activity of CD45 is a function of the first phosphatase domain (D1) while the second phosphatase domain (D2) may interact with and stabilize the first domain, or recruit/bind substrates (2, 3). CD45 interacts directly with antigen receptor complex proteins or activates Src family kinases involved in the regulation of T-and B-cell antigen receptor signaling (1). Specifically, CD45 dephosphorylates Src-family kinases Lck and Fyn at their conserved negative regulatory carboxy-terminal tyrosine residues and upregula |
| Immunogen | Immunogen: A synthetic peptide of human PTPRC Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [B220; CD45; CD45R; GP180; LCA; LY5; T200] |
| Gene, Accession # | [PTPRC], Gene ID: 5788, NCBI: NP_002829.3, UniProt: P08575 |
| Catalog # | MBS8503990 |
| Price | $310 |
| Order / More Info | PTPRC Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Huntington, N.D. and Tarlington, D.M. (2004) Immunol. Lett. 94, 167-174. 2. Felberg, J. and Johnson, P. (2000) Biochem. Biophys. Res. Commun. 271, 292-298. 3. Kashio, N. et al. (1998) J. Biol. Chem. 273, 33856-33863. 4. Wang, Y. and Johnson, P. (2005) J. Biol. Chem. 280, 14318-14324. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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