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Antigenic Specificity | Lipin 1 (LPIN1), |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1 target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPAR. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insuli |
Immunogen | Immunogen: A synthetic peptide to an internal region (within residues 300-400) of the human LPIN1 protein. [Swiss-Prot# Q14693]. |
Other Names | [phosphatidate phosphatase LPIN1 isoform 2; Phosphatidate phosphatase LPIN1; phosphatidate phosphatase LPIN1; lipin 1; Lipin-1], [LPIN1; LPIN1; PAP1; KIAA0188] |
Gene, Accession # | [LPIN1], Gene ID: 23175, NCBI: NP_001248356.1 |
Catalog # | MBS555111 |
Price | $430 |
Order / More Info | Lipin 1 (LPIN1), Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |