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Antigenic Specificity | CD46 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-320 of human CD46 (NP 722548.1). |
Other Names | [MCP; TLX; AHUS2; MIC10; TRA2.10] |
Gene, Accession # | [CD46], Gene ID: 4179, NCBI: P15529.3, UniProt: P15529 |
Catalog # | MBS8544509 |
Price | $280 |
Order / More Info | CD46 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |