Edit |   |
---|---|
Antigenic Specificity | PKC iota, NT |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | ammonium sulfate precipitate |
Size | 0.2 mL |
Concentration | 1.41mg/ml |
Applications | ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes human PKC. PKC iota belongs to the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehydes-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosi |
Immunogen | Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 176-207 in the N-terminal region of human PKC iota, UniProt Accession #P41743. |
Other Names | PKC iota, NT (Protein Kinase C iota Type, Atypical Protein Kinase C-lambda/iota, PRKC-lambda/iota, aPKC-lambda/iota, nPKC-iota, PRKCI, DXS1179E) |
Gene, Accession # | Gene ID: 5584, NCBI: NP_002731.4, UniProt: P41743 |
Catalog # | MBS624797 |
Price | $610 |
Order / More Info | PKC iota, NT Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |