Description | Specificity: Human CD51. CD51 represents the 150 kDa integrin alpha V chain that associates with integrin beta 3 (CD61) to form the CD51/CD61 vitronectin receptor on endothelial cells, certain activated leukocytes, NK cells, macrophages, neutrophils and platelets. CD51 is the most promiscuous integrin a subunit; it can form heterodimers with the beta 1 (CD29), beta 3 (CD61), beta 5, beta 6 and beta 8 subunits in various tissues. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins, including matrix components. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31.1-4. |
Product Specific References | 1. Knapp, W., B. Dorken, W.R. GIlks, E.P. Rieber, R.E. Schmidt, H. Stein, A.E.G.K. Von dem Borne, eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, Oxford.2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD51 Section, Academic Press, New York, p. 271.3. Keiffer, N., and D.R. Phillips. 1990. Annu. Rev. Cell. Biol. 6:329.4. Ginsberg, M.H., D. Xiaoping, T.E. O'Toole, J.C. Loftus, and E.F. Plow. 1993. Thromb. Haemost. 70:87. |