MAP3K8 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | MAP3K8 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat. |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) detection. Background: Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene. This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. Additionally, this protein was found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform |
| Immunogen | Immunogen: E Coli-derived human MAP3K8 recombinant protein (Position: D9-L193). Human MAP3K8 shares 89.7% and 90.3% amino acid (aa) sequence identity with mouse and rat MAP3K8, respectively. |
| Other Names | [c COT; c-COT; CCOT; COT; EST; ESTF; MAP3K 8; MAP3K8; MEKK8; TPL2; TPL-2; TPL 2; P41279; Mitogen-activated protein kinase kinase kinase 8], [MAP3K8; MAP3K8; COT; EST; ESTF; TPL2; AURA2; MEKK8; Tpl-2; c-COT; COT; ESTF; TPL-2] |
| Gene, Accession # | [MAP3K8], Gene ID: 1326, NCBI: NP_001231063.1, UniProt: P41279 |
| Catalog # | MBS178507 |
| Price | $315 |
| Order / More Info | MAP3K8 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Entrez Gene: MAP3K8 mitogen-activated protein kinase kinase kinase 8.2. Chan AM, Chedid M, McGovern ES, Popescu NC, Miki T, Aaronson SA (May 1993). Expression cDNA cloning of a serine kinase transforming gene. Oncogene 8 (5): 1329-33.3. Miyoshi J, Higashi T, Mukai H, Ohuchi T, Kakunaga T (Aug 1991). Structure and transforming potential of the human cot oncogene encoding a putative protein kinase. Molecular and Cellular Biology 11 (8): 4088-96. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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