I-Kappa-B Kinase b (IKKb) Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | I-Kappa-B Kinase b (IKKb) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody reacts with human, mouse and rat. The other species are not tested. IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. IKK is a serine protein kinase which can activate NF-kB. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Addit |
| Immunogen | n/a |
| Other Names | [I-Kappa-B Kinase b; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; IKKB; NFKBIKB; IKK-beta], [IKBKB; IKBKB; IKK2; IKKB; IMD15; NFKBIKB; IKK-beta; IKKB; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; IKK2; NFKBIKB] |
| Gene, Accession # | [IKKb], Gene ID: 3551, NCBI: NP_001177649.1, UniProt: O14920 |
| Catalog # | MBS460279 |
| Price | $285 |
| Order / More Info | I-Kappa-B Kinase b (IKKb) Antibody from MYBIOSOURCE INC. |
| Product Specific References | DiDonato, J.A., Hayakawa, M., Rothwarf, D.M., Zandi, E. and Karin, M. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388 (6642), 548-554 (1997) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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