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Antigenic Specificity | RARA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA), ChIP |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polyclonal Antibody to detect RARA in human samples. Background: RARA is a receptor for retinoic acid, a vitamin A metabolite, which directly regulates gene expression in target cells by binding to specific DNA response elements. In the absence of its ligand, this receptor represses transcription through the recruitment of specific corepressors and of HDAC's, whereas binding of retinoic acid causes the recruitment of coactivators and HAT's. Translocations involving the RARA gene, often leading to a RARA/PML fusion protein, are a major cause of acute promyelocytic leukemia. |
Immunogen | Immunogen: Human RARA (Retinoic Acid Receptor alpha) using two KLH-conjugated synthetic peptides containing sequences from the C-terminal region of the protein. Positive Control: Western blot: Human embryonic kidney cells, ELISA: peptides, ChIP: NB4 cells. |
Other Names | [Retinoic acid receptor alpha; Nuclear receptor subfamily 1 group B member 1; NR1B1], [RARA; RARA; RAR; NR1B1; NR1B1; RAR-alpha] |
Gene, Accession # | [RARA], Gene ID: 5914, NCBI: NP_000955.1, UniProt: P10276 |
Catalog # | MBS840323 |
Price | $290 |
Order / More Info | RARA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |