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Antigenic Specificity | Catenin, beta (p120) |
Clone | [15B8] |
Host Species | Mouse |
Reactive Species | human, mouse, rat, cow, dog, chicken. |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, som |
Immunogen | Immunogen: Recombinant chicken ?-catenin. Cellular Localization: Cell Surface and Cytoplasmic |
Other Names | [Cadherin associated protein; beta 1 88kDa; Catenin beta-1; CATNB; CHBCAT; CTNNB1], [CTNNB1; CTNNB1; EVR7; CTNNB; MRD19; armadillo; CTNNB] |
Gene, Accession # | [CTNNB1], Gene ID: 1499, NCBI: NP_001091679.1, UniProt: P35222 |
Catalog # | MBS439896 |
Price | $190, $340, $340 |
Order / More Info | Catenin, beta (p120) Antibody from MYBIOSOURCE INC. |
Product Specific References | Dabbs DJ et. al. Am J Surg Path. 2007; 31:427-437. Sarrio D et. al. Oncogene. 2004; 23:3272-3283. Mastracci TL et. al. Mod Path. 2005; 18:741-751. |