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Antigenic Specificity | Phospho-rat TSC1 (S1141) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.28 |
Applications | Dot Blot (DB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This rat TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1141 of rat TSC1. In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). |
Immunogen | n/a |
Other Names | [Hamartin; Tuberous sclerosis 1 protein homolog; Tsc1] |
Gene, Accession # | [Tsc1], Gene ID: 60445, NCBI: NP_068626.1, UniProt: Q9Z136 |
Catalog # | MBS9200876 |
Price | $165, $370 |
Order / More Info | Phospho-rat TSC1 (S1141) Antibody from MYBIOSOURCE INC. |
Product Specific References | Inoue, H., et al. Biosci. Biotechnol. Biochem. 73(11):2488-2493(2009) Di Nardo, A., et al. J. Neurosci. 29(18):5926-5937(2009) Chen, P., et al. Exp. Mol. Pathol. 86(2):101-107(2009) Momose, S., et al. Biochem. Biophys. Res. Commun. 356(3):693-698(2007) Goncharova, E., et al. J. Cell Biol. 167(6):1171-1182(2004) |