Edit |   |
---|---|
Antigenic Specificity | AP2M1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The AP-2 coat assembly protein complex is an important component of clathrin-coated pits involved in receptor-mediated endocytosis at the plasma membrane (1-3). Each AP-2 heterotetramer is composed of alpha, beta, mu, and sigma protein subunits. The 50 kDa mu subunit (AP-2mu, AP2M1) is located at the core of the AP-2 complex and mediates interaction between the cargo protein and the clathrin-coated pit (1-4). The carboxy-terminal AP2M1 region recognizes the tyrosine-based, endocytotic sorting motif YXXphi found in cargo proteins and helps to bring the cargo protein to the clathrin-coated pit. Non-canonical, tyrosine-based endocytotic sorting signals can also promote interaction between cargo proteins and AP2M1 (5, 6). AP2M1 plays an essenti |
Immunogen | Immunogen: Recombinant protein of human AP2M1 Observed Molecular Weight: 49kDa |
Other Names | [AP50; CLAPM1; mu2] |
Gene, Accession # | [AP2M1], Gene ID: 1173, NCBI: NP_001020376.1 |
Catalog # | MBS2527008 |
Price | $150, $225, $360 |
Order / More Info | AP2M1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |