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Antigenic Specificity | CAMK4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 304-473 of human CAMK4 (NP 001735.1). |
Other Names | [caMK; CaMK IV; CaMK-GR] |
Gene, Accession # | [CAMK4], Gene ID: 814, NCBI: NP_001735.1, UniProt: Q16566 |
Catalog # | MBS8545487 |
Price | $280 |
Order / More Info | CAMK4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |