Notch1 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Notch1 |
| Clone | [S253-32] |
| Host Species | Mouse |
| Reactive Species | mouse, rat |
| Isotype | IgG1 |
| Format | ATTO 488 conjugate |
| Size | 0.1 mg |
| Concentration | 1mg/mL |
| Applications | Western Blot (WB), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background Info: Detects >270kDa, ~120kDa and small fragments due to proteolysis. Does not cross-react with Notch2 or Notch3. Scientific Background: Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cl |
| Immunogen | n/a |
| Other Names | [Neurogenic locus notch homolog protein 1; hN1; Translocationassociated notch protein; TAN-1; Motch A; mT14; p300; Notch 1; Notch-1], [Notch1; Notch1; N1; Mis6; Tan1; lin-12; 9930111A19Rik; Motch; Notch 1; NEXT; NICD] |
| Gene, Accession # | Gene ID: 18128, NCBI: NP_032740.3, UniProt: Q01705 |
| Catalog # | MBS800066 |
| Price | $440 |
| Order / More Info | Notch1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Swiatek P.J., et al. (1994) Genes Dev. 8: 707-719. 2. Simpson P. (1994) The Notch Receptors. Austin, TX: R.G. Landes Company. 3. Lindsell C.E., et al. (1995) Cell 80: 909-917. 4. Uyttendaele H., et al. (1996) Development 122: 2251-2259. 5. Girard L., et al. (1996) Genes Dev. 10: 1930-1944. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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