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Antigenic Specificity | CCR3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells. CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS. High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems. The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 play |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 14 amino acid peptide from near the carboxy terminus of human CCR3. |
Other Names | [CC chemokine receptor 3, eosinophil eotaxin receptor] |
Gene, Accession # | [CCR3], Gene ID: 1232, NCBI: NP_847899 |
Catalog # | MBS9406076 |
Price | $320 |
Order / More Info | CCR3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |