Human Granzyme B Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human Granzyme B |
| Clone | [GM-4C1] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), CELISA, ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: anti-human Granzyme B (GrB, granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1). Background: Granzyme B (GrB) is a 27 kDa caspase-like serine protease that is released by activated cytotoxic T cells and natural killer cells to kill virus-infected and tumor cells (1). The enzymatic activity of granzyme B is considered essential to its ability to induce cell death through the activation of caspases. It has the strongest apoptotic activity of all granzymes, as a result of its caspase-like ability to cleave substrates at key aspartic acid residues (1,2). GrB is involved in several pathologies including viral infections, graft rejection, graft-vs.-host disease (2,3), rheumatoid arthritis and plays an important role in a |
| Immunogen | Immunogen: Immunogen: cDNA |
| Other Names | [granzyme B; granzyme B; C11; CTLA-1; fragmentin 2; fragmentin-2; cathepsin G-like 1; human lymphocyte protein; T-cell serine protease 1-3E; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase 2; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E], [GZMB; GZMB; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1; CGL1; CSPB; CTLA1; GRB; CTSGL1; Lymphocyte protease; HLP] |
| Gene, Accession # | Gene ID: 3002, NCBI: NP_004122.2, UniProt: P10144 |
| Catalog # | MBS468009 |
| Price | $505 |
| Order / More Info | Human Granzyme B Antibody from MYBIOSOURCE INC. |
| Product Specific References | Trapani JA (2001). Granzymes a family of lymphocyte granule serine proteases. Genome Biol2(12):REVIEWS3014.Trapani JA, Sutton VR (2003). Granzyme B: pro-apoptotic, antiviral and antitumor functions.Curr Opin Immunol 15(5):533-43.Graubert TA, DiPersio JF, Russell JH and Ley TJ (1997). Perforin/granzyme-dependent andIndependent Mechanisms are Both Important for the Development of Graft-versus-host DiseaseAfter Murine Bone Marrow Transplantation. J Clin Invest 100(4): 904-911 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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