Edit |   |
Antigenic Specificity | TLR7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated ac |
Immunogen | Immunogen: Recombinant protein of human TLR7 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [TLR7] |
Gene, Accession # | [TLR7], Gene ID: 51284, NCBI: NP_057646.1, UniProt: Q9NYK1 |
Catalog # | MBS8504985 |
Price | $310 |
Order / More Info | TLR7 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Akira, S. (2003) J Biol Chem 278, 38105-8. 2. Beutler, B. (2004) Nature 430, 257-63. 3. Dunne, A. and O'Neill, L.A. (2003) Sci STKE 2003, re3. 4. Chuang, T.H. and Ulevitch, R.J. (2000) Eur Cytokine Netw 11, 372-8. 5. Du, X. et al. (2000) Eur Cytokine Netw 11, 362-71. 6. Heil, F. et al. (2003) Eur J Immunol 33, 2987-97. 7. Hemmi, H. et al. (2002) Nat Immunol 3, 196-200. 8. Heil, F. et al. (2004) Science 303, 1526-9. 9. Diebold, S.S. et al. (2004) Science 303, 1529-31. 10. Lund, J.M. et al. (2004) Proc Natl Acad Sci USA 101, 5598-603. |