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Antigenic Specificity | MCL1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Western blot analysis of extracts of various cell lines, using MCL1 antibody. Mcl-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway (1). Similar to other Bcl-2 family members, Mcl-1 localizes to the mitochondria (2), interacts with and antagonizes pro-apoptotic Bcl-2 family members (3), and inhibits apoptosis induced by a number of cytotoxic stimuli (4). Mcl-1 differs from its other family members in its regulation at both the transcriptional and post-translational level. First, Mcl-1 has an extended amino-terminal PEST region, which is responsible for its relatively short half-li |
Immunogen | Immunogen: Recombinant protein of human MCL1 |
Other Names | [MCL1, partial; Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; myeloid cell leukemia sequence 1; Bcl-2-related protein EAT/mcl1], [Mcl1; Mcl1; Mcl-1; AW556805] |
Gene, Accession # | [MCL1], Gene ID: 17210, NCBI: AAC27929.1 |
Catalog # | MBS419445 |
Price | $385 |
Order / More Info | MCL1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |