Caspase-8 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Caspase-8 |
| Clone | [2E3] |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG |
| Format | Protein A purified |
| Size | 0.02 mL, 0.06 mL, 0.12 mL |
| Concentration | 1mg/mL |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-AMC. Likely target fo |
| Immunogen | Immunogen: Recombinant Protein Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.4 Conjugation: Unconjugated |
| Other Names | [caspase-8 isoform C; Caspase-8; caspase-8; caspase 8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE] |
| Gene, Accession # | Gene ID: 841, NCBI: NP_001073593.1, UniProt: Q14790 |
| Catalog # | MBS2548885 |
| Price | $110, $150, $225 |
| Order / More Info | Caspase-8 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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