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Antigenic Specificity | LARP7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: LARP7 antibody detects endogenous levels of LARP7. Function: Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.Subunit Structure: Integral part of the 7SK RNP complex (PubMed:18483487). Specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA (PubMed:18483487). On stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18483487). Interacts with METTL16 (PubMed:29051200). |
Immunogen | Immunogen: A synthesized peptide derived from human LARP7. Subcellular Location: Nucleus > Nucleoplasm. Predicted Cross Reactivity: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity: Pig (83%), Zebrafish (92%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (92%) |
Other Names | [DKFZp564K112; HDCMA18P; La related protein 7; La ribonucleoprotein domain family member 7; La ribonucleoprotein domain family member 7; La-related protein 7; LARP 7; larp7; LARP7_HUMAN; MGC104360; P TEFb interaction protein for 7SK stability; P-TEFb-interaction protein for 7SK stability; PIP7S] |
Gene, Accession # | [LARP7], Gene ID: 51574, NCBI: NP_001253968.1, UniProt: Q4G0J3 |
Catalog # | MBS9603436 |
Price | $240, $280 |
Order / More Info | LARP7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |