RRP8 - N-terminal region Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | RRP8 - N-terminal region |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | cow, dog, guinea pig, horse, human, rabbit, rat, yeast |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This is a rabbit polyclonal antibody against RRP8. It was validated on Western BlotTarget Description: RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. |
| Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human RRP8 |
| Other Names | [ribosomal RNA-processing protein 8; Ribosomal RNA-processing protein 8; ribosomal RNA-processing protein 8; ribosomal RNA processing 8; Cerebral protein 1; Nucleomethylin] |
| Gene, Accession # | [RRP8], Gene ID: 23378, NCBI: NP_056139, UniProt: O43159 |
| Catalog # | MBS3217869 |
| Price | $335 |
| Order / More Info | RRP8 - N-terminal region Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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